Association of weight gain and metabolic syndrome in patient taking Clozapine: a 8-year cohort study

Association of weight gain and metabolic syndrome in patients taking clozapine: an 8-year cohort study.

INTRODUCTION Metabolic syndrome is an important side effect associated with clozapine. It has been hypothesized that weight gain contributes to the development of metabolic syndrome, but a direct diabetogenic effect has also been suggested. We conducted an 8-year cohort study to determine the association between weight gain and metabolic parameters among schizophrenic patients taking clozapine....

Genetic Polymorphisms in the HTR2C and Peroxisome Proliferator-Activated Receptors Are Not Associated with Metabolic Syndrome in Patients with Schizophrenia Taking Clozapine

OBJECTIVE Genetic variation in the serotonin-2C receptor encoded by the HTR2C gene is one of the genetic determinants of antipsychotic-induced weight gain. Peroxisome proliferator-activated receptors are nuclear receptors regulating the expression of genes involved in lipid and glucose metabolism. In this cross-sectional study, we investigated whether HTR2C-759C/T, HTR2C-697G/C, PPARα V227A, an...

Interactions between Weight Change and Fruit and Vegetable Intake in the Incidence of Metabolic Syndrome: The Tehran Lipid and Glucose Study

Introduction: This study aimed to investigate the interactions of weight change and fruit and vegetable intake with the incidence of metabolic syndrome (MetS) among adults. Materials and Methods: This study was conducted within the framework of the Tehran Lipid and Glucose Study (TLGS) among 1915 adults during 8.9 years of follow-up. Dietary data were assessed using the food frequency questionn...

The Association Between Pre-Pregnancy Body Mass Index and Gestational Weight Gain on Pregnancy Outcomes: A Retrospective Cohort Study

The relationship between shift work and metabolic syndrome: a prospective cohort study

Background: Metabolic syndromes have been identified as a major risk factor for people with cardiovascular disease. Metabolic syndromes are defined as a range of conditions including waist-fat, abdominal obesity, high blood pressure, diabetes, high triglycerides, and HDL. Considering the importance of controlling metabolic syndrome, the research study subject with the mentioned aim is so import...